Biomolecular Action of Ionizing Radiation.

Summary

Titles

• Full Title: Biomolecular Action of Ionizing Radiation.

Series Statement

• 
  Warning: Array to string conversion in /home/h287505/domains/world-catalogue.com/public_html/wp-includes/formatting.php on line 1128
  Array

Notes

• Mutants.
• Front cover -- Series Blurb -- Series Preface -- Contents -- Acknowledgments -- Abbreviations -- Chapter 1. Introduction -- Chapter 2. Basic Radiation Physics and Chemistry -- Chapter 3. Basic Cell Biology and Molecular Genetics -- Chapter 4. Methods of Cell and Molecular Radiobiology -- Chapter 5. Ionizing Radiation Effects to the Cytoplasm -- Chapter 6. Damage to DNA by Ionizing Radiation -- Chapter 7. Repair of Radiation Damage to DNA -- Chapter 8. Cellular Response to DNA Damage -- Chapter 9. Chromatin Structure and Radiation Sensitivity -- Chapter 10. Radiation-Induced Chromosome Damage -- Chapter 11.Modulation of Radiation Response via Signal Transduction Pathways -- Chapter 12. Radiation-Induced Apoptosis -- Chapter 13. Early and Late Responding Genes Induced by Ionizing Radiation -- Chapter 14. Cell Death, Cell Survival, and Adaption -- Chapter 15. Bystander Effects and Genomic Instability -- Chapter 16. Tumor Radiobiology -- Chapter 17. Radiation Biology of Nonmammalian Species: Three Eukaryotes and a Bacterium -- Glossary -- Index -- Back cover.

Identifiers

• Isbns: 9781420011920; 1420011928
• Oclc Number: (OCoLC)1058196539

Publication Statement

• Place: London
• Publisher: CRC Press
• Date: 2008; 2007

Physical Description

• Extent: 1 online resource (564 pages).

Table Of Contents

• Front cover -- Series Blurb -- Series Preface -- Contents -- Acknowledgments -- Abbreviations -- Chapter 1. Introduction -- Chapter 2. Basic Radiation Physics and Chemistry -- Chapter 3. Basic Cell Biology and Molecular Genetics -- Chapter 4. Methods of Cell and Molecular Radiobiology -- Chapter 5. Ionizing Radiation Effects to the Cytoplasm -- Chapter 6. Damage to DNA by Ionizing Radiation -- Chapter 7. Repair of Radiation Damage to DNA -- Chapter 8. Cellular Response to DNA Damage -- Chapter 9. Chromatin Structure and Radiation Sensitivity -- Chapter 10. Radiation-Induced Chromosome Damage -- Chapter 11.Modulation of Radiation Response via Signal Transduction Pathways -- Chapter 12. Radiation-Induced Apoptosis -- Chapter 13. Early and Late Responding Genes Induced by Ionizing Radiation -- Chapter 14. Cell Death, Cell Survival, and Adaption -- Chapter 15. Bystander Effects and Genomic Instability -- Chapter 16. Tumor Radiobiology -- Chapter 17. Radiation Biology of Nonmammalian Species: Three Eukaryotes and a Bacterium -- Glossary -- Index -- Back cover.

Summary

• INTRODUCTION BASIC RADIATION PHYSICS AND CHEMISTRY Ionization and Excitation Types of Ionizing Radiation Electromagnetic Radiation Particulate Radiations Processes of Energy Absorption Direct and Indirect Action of Radiation Radiolysis of Water Haber-Weiss Reaction Reactions of the Primary Radiolytic Products of Water with Target Molecules Solute Radicals Form Stable Products Linear Energy Transfer Relative Biological Effectiveness BASIC CELL BIOLOGY AND MOLECULAR GENETICS Basic Cell Biology Cell Membrane Cytoplasm Nucleus Mitochondria Endoplasmic Reticulum and Ribosomes Golgi Complex Cytoskeleton Lysosomes Extracellular Materials Molecular Genetics DNA Structure DNA Structure Is the Basis for Heredity Mechanism of DNA Replication Transcribing DNA to RNA From RNA to Protein Proteins METHODS OF CELL AND MOLECULAR RADIOBIOLOGY Methods of Classical Radiobiology Cell Survival In Vitro: The Clonogenic Assay Non-Clonogenic Assays Methods of Cell Synchronization Determination of Duration of Phases of the Cell Cycle Measuring Cell Survival In Vivo Methods for Detecting Damage to DNA Strand Break Assays Measurement of DNA Damage and Repair in Individual Mammalian Cells Tools and Techniques of Molecular Biology Hybridization of Nucleic Acids Restriction Enzymes Gel Electrophoresis and Blotting Techniques Polymerase Chain Reaction Putting New Genes into Cells: DNA-Mediated Gene Transfer Generation of a Cloned Probe or DNA Library Sequencing of DNA Single Nucleotide Polymorphisms Functional Inactivation of Genes Genomic Methods of Tumor Analysis Analysis of Proteins Production of Monoclonal Antibodies Proteomics: Analysis of Protein Structure and Function Analysis of Tissue Sections and Single Cells Laser Capture Microdissection IONIZING RADIATION EFFECTS TO THE CYTOPLASM.
• Oxidative Stress Metabolic Oxidative Stress Ionizing Radiation-Induced ROS/RNS Demonstration of Radiation-Induced Intracellular ROS/RNS Mechanisms of Generation and Amplification of ROS/RNS Following Irradiation of the Cytoplasm Consequences of Radiation-Induced Generation of ROS/RNS Effects of Ionizing Radiation on the Cell Membrane Structure of the Cell Membrane Lipid Peroxidation in Plasma Membranes Consequences of Damage to Plasma Membrane Lipids Plasma Membrane Is a Target for Ionizing Radiation-Induced Apoptosis DAMAGE TO DNA BY IONIZING RADIATION Mechanisms of DNA Damage: Physicochemical Relationships Mechanisms of Damage Induction: Chemical End Points Mechanisms of Damage Induction: Cellular End Points Types of DNA Damage Simple Damages to DNA: Base Damage and Single-Strand Breaks Apurinic or Apyrimidinic Sites Modifiers of Radiation Effect DNA Strand Breaks Double-Strand Breaks and Other Multiply Damaged Sites Distribution of MDS Clustered Damage in DNA of Mammalian Cells DNA-Protein Cross-Links REPAIR OF RADIATION DAMAGE TO DNA Overview of DNA Repair Mechanisms Repair of Radiation-Induced DNA Damage Repair of Base Damage and Single-Strand DNA Breaks: Base Excision Repair Role of PARP Processing of Multiply Damaged Sites by BER Repair of DNA Double-Strand Breaks Homologous Recombination Nonhomologous End Joining Genes and Proteins Involved in NHEJ Telomere-Bound Proteins and DNA Repair Human Syndromes Involving DNA Repair Deficiency Relationship between DNA Repair and Cell Survival CELLULAR RESPONSE TO DNA DAMAGE Passing on the Message that DNA Has Been Damaged Signal Transduction Signal Transduction Cascade Initiated by Radiation-Induced DNA Damage ATM Protein Functions of ATM How Does ATM Respond to Radiation-Induced DNA Damage? Role of ATM in DNA Repair ATM and.
• The MRN Complex Tumor Suppressor Gene p53 Turnover of p53: Mdm2 Modulation of p53 Stability and Activity Radiation-Induced Growth Arrest Cell Cycle: Cyclins and Cyclin Dependent Kinases. Radiation-Induced Cell-Cycle Arrest Oncogenes and Cell-Cycle Checkpoints Variation in Radiosensitivity through the Cell Cycle P53-Mediated Apoptosis CHROMATIN STRUCTURE AND RADIATION SENSITIVITY Cell Nucleus Hierarchical Structure of Chromatin Structure and Function: Chromatin and the Nuclear Matrix Protection of DNA from Radiation Damage by Nuclear Proteins DNA-Protein Cross-Link Formation DSB Yields and RBE Role of Polyamines Radiation Sensitivity and the Stability of the DNA-Nuclear Matrix Radiosensitivity of Condensed Chromatin Role of Chromatin in DNA DSB Recognition and Repair Histone 2AX ATM Signaling from Chromatin Modulation of Chromatin Structure and Function by Acetylation Radiosensitization by Histone Deacetylase Inhibitors RADIATION-INDUCED CHROMOSOME DAMAGE DNA, Chromosomes, and the Cell Cycle Organization of DNA into Chromatin and Chromosomes Cell Cycle Mitosis Radiation-Induced Chromosome Aberrations Nature of the Initial Lesion Partial Catalog of Chromosome and Chromatid Aberrations Visualization of Chromosome Breaks during Interphase: Premature Chromosome Condensation FISH, mFISH, SKY, mBAND FISH, and Chromosome Painting Results of Whole Chromosome Painting Mechanisms of Aberration Formation Chromosome Localization and Proximity Effects Implications of Chromosome Damage Genetics Carcinogenesis Cell Survival, Dose Rate, and Fractionation Response Genomic Instability Biodosimetry and Risk Estimation MODULATION OF RADIATION RESPONSE VIA SIGNAL TRANSDUCTION PATHWAYS Intracellular Signaling Transmembrane Receptors ErbB Family of Receptor Kinases Cytoplasmic Signaling Ras.
• Proto-Oncogene Family Signal Transduction Cascades Modulation of Radiation Response by Interaction of Signal Transduction Pathways Activation of ErbB Receptors by Ionizing Radiation Mechanism of Receptor Activation by Ionizing Radiation Role of Other Growth Factors Effects of Activation of GF Receptors on Cell Survival Autocrine Signaling Radiosensitization by Modulation of Signal Transduction Intermediates: Molecular Radiosensitizers ErbB Family Signal Inhibitors Clinical Applications of EGFR Signal Inhibitors Inhibition of the Ras-Mediated Signaling Pathway Clinical Application of Farnesyl Transferase Inhibitors Clinical Implications of Radiation-Induced Cell Signaling: Accelerated Cell Proliferation RADIATION-INDUCED APOPTOSIS Apoptosis Mechanisms of Apoptosis Caspases Apoptotic Signaling Pathways Intrinsic Apoptotic Signaling: The Mitochondrial Pathway Extrinsic Apoptotic Signaling Extrinsic Apoptotic Signaling Initiated at the Plasma Membrane: The Ceramide Pathway Why Do Some Cells Die as the Result of Apoptosis and Not Others? Apoptotic Processes and the In Vivo Radiation Response Normal Tissue Tumor Response EARLY AND LATE RESPONDING GENES INDUCED BY IONIZING RADIATION Gene Expression Is Induced by Ionizing Radiation Transcription Factors Important Transcription Factors Activated by Radiation Radiation-Gene Therapy Early and Late Response Genes Induction of Late Response Genes by Ionizing Radiation Cytokine-Mediated Responses in Irradiated Tissues Late Effects: Radiation-Mediated Fibrosis Gene Expression Associated with Radiation-Mediated Vascular Damage Cytokines as Therapeutic Agents: Radioprotection and Radiosensitization Radiosensitization Radioprotection Cytokines as Biomarkers of Radiation Exposure CELL DEATH, CELL SURVIVAL, AND ADAPTATION Cell Death Modes of Cell.
• Death in Nonirradiated Cells Radiation-Induced Cell Death Role of p53 Quantitating Cell Kill: Analysis of Cell Survival Curves Target Theory Linear Quadratic Model Lethal, Potentially Lethal Damage Model Repair Saturation Models Cell Survival at Low Radiation Doses Low Dose Hypersensitivity Adaptive Response Interactions of Adaptive Response and Bystander Effects Implications of Low Dose Effects for Risk Assessment Exposure to Background Radiation Adaptive Response and Neoplastic Transformation Clinical Implications of Low Dose Effects BYSTANDER EFFECTS AND GENOMIC INSTABILITY Dogma of Radiation Biology Bystander Effects Bystander Effects In Vitro Bystander Effects Seen after Transfer of Medium from Irradiated Cells Bystander Effects In Vivo Mechanisms Underlying Radiation-Induced Bystander Effects Implications in Risk Assessment Genomic Instability Genomic Instability In Vitro: Delayed Responses to Radiation Exposure Demonstration of Genomic Instability In Vivo Genomic Instability and Cancer Mechanisms Underlying Radiation-Induced Genomic Instability Relationship between Radiation-Induced Bystander Effects and Genomic Instability TUMOR RADIOBIOLOGY Tumor Radiobiology Unique Tumor Microenvironment Interstitial Fluid Pressure Tumor Hypoxia Tumor Acidosis Tumor Metabolism: Aerobic and Anaerobic Glycolysis Tumor Microenvironment Creates Barriers to Conventional Therapies Chemotherapy Radiotherapy Measurement of Tumor Hypoxia Radio-Sensitization by Modifying Tumor Oxygenation Effect of Hypoxia on Tumor Development and Progression Targeting the Ubiquitin/Proteasome System RADIATION BIOLOGY OF NONMAMMALIAN SPECIES: THREE EUKARYOTES AND A BACTERIUM Introduction: Lower Eukaryotes in Radiation Research Yeast, a Single-Celled Eukaryote Radiation Biology of Yeast Radiosensitive.

Subjects

Writers